Tissue specific regulation of transcription in endometrium and association with disease

S Mortlock; RI Kendarsari; JN Fung; G Gibson; F Yang; R Restuadi; JE Girling; SJ Holdsworth-Carson; WT Teh; SW Lukowski; M Healey; T Qi; PAW Rogers; J Yang; B McKinnon; GW Montgomery

Journal article

Tissue specific regulation of transcription in endometrium and association with disease

S Mortlock, RI Kendarsari, JN Fung, G Gibson, F Yang, R Restuadi, JE Girling, SJ Holdsworth-Carson, WT Teh, SW Lukowski, M Healey, T Qi, PAW Rogers, J Yang, B McKinnon, GW Montgomery

Human Reproduction | Published : 2020

DOI: 10.1093/humrep/dez279

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Abstract

Are genetic effects on endometrial gene expression tissue specific and/or associated with reproductive traits and diseases? SUMMARY ANSWER: Analyses of RNA-sequence data and individual genotype data from the endometrium identified novel and disease associated, genetic mechanisms regulating gene expression in the endometrium and showed evidence that these mechanisms are shared across biologically similar tissues. WHAT IS KNOWN ALREADY: The endometrium is a complex tissue vital for female reproduction and is a hypothesized source of cells initiating endometriosis. Understanding genetic regulation specific to, and shared between, tissue types can aid the identification of genes involved in comp..

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University of Melbourne Researchers

Sarah Holdsworth-Carson Author

Martin Healey Author

Peter Rogers Author

Wan Teh Author

Related Projects (1)

IDENTIFICATION AND FUNCTION OF GENES THAT INCREASE RISK FOR ENDOMETRIOSIS

Endometriosis is a common disease that affects 7% of reproductive age women in Australia, resulting in pelvic pain, subfertility and painful..

Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

National Health and Medical Research Council (NHMRC) under project grants GNT1026033, GNT1049472, GNT1046880, GNT105 0208, GNT1105321, GNT1083405 and GNT1107258; NHMRC Fellowship (GNT1078399) to G.W.M.; Australian Research Council (ARC) Fellowship (FT180100186) to J.Y.